Buy Carisoprodol

Carisoprodol history

On June 1st 1959 several American pharmacologist convened at Wayne State University, Detroit, MI to discuss a new drug.

The drug, originally thought to have antiseptic properties, was found to have central muscle relaxing properties. It had been developed by Dr. Frank M. Berger at Wallace laboratories and had been named carisoprodol.

The misuse and abuse of meprobamate and other muscle relaxing drugs was an item of great concern in the 1950s and 1960s 3-5 . Carisoprodol i was developed in the 1950s on the basis of meprobamate, hoping that it would have better muscle-relaxing properties, less abuse-potential, and less risk of overdose than meprobamate 18 .

The substitution of one hydrogen atom with an isopropyl group on one of the carbamyl nitrogens was intended to yield a molecule with new pharmacological properties.

Carisoprodol versus Butabarbital

This results of a double-blind study have shown that carisoprodol is significantly more effective than butabarbital or placebo in producing improvement of all factors rated in treatment of the low back syndrome. The effects of carisoprodol are not due solely to sedative action, but are also related to its muscle relaxant activity.

The study was carried out to determine the effectiveness of carisoprodol in the treatment of the low back syndrome, and to test whether this drug would produce any greater effect than an active sedative control (butabarbital). 48 Mexican migrant farm laborers with acute lumbar strain and spasm were given either carisoprodol 350 mg, butabarbital 15 mg, or placebo, four times daily for four days, and then were rated on pertinent symptoms, the degree of limitation of motion, and overall improvement.

In the 43 patients who could be statistically analyzed, carisoprodol was shown to be significantly more effective than butabarbital or placebo in producing improvement.